Pharmacokinetics and Mechanism of Action of Dapoxetine

Dapoxetine For Sale - Introduction

Dapoxetine is a medication that is typically prescribed to those men who deal with premature ejaculation. The medicine is available under various brand and trade names. Some of these are Priligy and Westoxetin. Further, there are numerous other names in the market, as well.

Further, this medication is typically for men between the age of 18 and 64 years old. Besides, the availability of this drug is not something that you must worry about. It is because you can readily look for Dapoxetine for sale online these days.

Given below is a detailed overview of the mechanism of action of this drug along with its pharmacokinetics. Have a look:

Premature Ejaculation – A Brief Overview

Before we get into the details of how this medication will work for you, it is a wise idea to understand a little about the condition that this medication can cure. It is Premature Ejaculation and a few of its names that people may know are early ejaculation, rapid climax, rapid ejaculation, premature climax/ also, historically, this condition was referred to as ejaculatio praecox.

Further, this is the state where when a man experiences an orgasm in sexual activity, he expels semen with a few moments of beginning it. There is no particular time or special norms that will define this premature state. However, generally, it is considered the same if it occurs between fifteen seconds to a minute after penetration.

Further, this period is otherwise four to eight minutes. And if it lasts even longer, this is again a serious condition that is generally referred to as delayed ejaculation. But it is not something that we are dealing with here. Furthermore, PE is a serious condition as it can cause emotional distress in those dealing with it and may also affect their relationships.

Mechanism of Action of Dapoxetine

Now since we know what Premature ejaculation is, knowing how Dapoxetine works before you start consuming, it is important as well. Thus, if you are about to begin your Dapoxetine treatment, you are in the right place. Also, you can buy Dapoxetine online in the USA.

The medication performs its action by producing an inhibiting effect on the serotonin transporter in your body. This, in turn, increases the serotonin level, thereby amplifying its action when it reaches the postsynaptic cleft. This will, therefore, help you by promoting the ejaculatory delay.

Further, not many may know that this medicine was earlier made with the motive of launching it as an antidepressant. But due to the fast-acting property of getting absorbed rapidly and then its super- soon elimination, premature ejaculation is what it is suitable for. And we are not complaining! This medicine sure does come handy for those dealing with PE.

Now, when it comes to the proper mechanism of action of Dapoxetine, it is still a matter of discussion. And thus, the mechanism is still unclear. The above theory is how experts in the medical field presume that it works. There is still no valid proof for the same. However, what is most important here is that it is really effective.

Besides, there are multiple areas in your Central Nervous System that regulate the ejaculation process. Typically, the pathway for this will initiate from a spinal reflex. This should further occur at the lumbosacral and thoracolumbar level of your brain stem.

Further, this can only occur by the stimulation of the male genital. Then, the signals from here are sent to your brain stem. Medial preoptic and paraventricular nuclei along with other numerous nuclei in your brain, may then influence it. Further, there were some clinical trials, as well. However, the exact mechanism of action of Dapoxetine is something that we still cannot tell about.

Pharmacokinetics – Movement of Dapoxetine in your body

After working, this is something you must know about to have a clear idea about the efficiency of this medicine. This, before you look for Dapoxetine for sale online, make sure you know the following:

Absorption of Dapoxetine

This white powdery substance is water-insoluble, and you must remember to take it at least one to three hours before your sexual activity. As soon as you consume it, your body will quickly absorb it. And you can experience the maximum effects within an hour or two. Further, you need not worry about the kind of food you need to have. And you can even have it on an empty stomach.

Distribution of Dapoxetine

Dapoxetine has a property of rapid absorption and similar id the case with the distribution of this drug. Further, more than 99% of this drug works by binding to the plasma protein.

Dapoxetine Metabolism and Excretion

This will occur in your liver and kidney. And there are multiple enzymes that will help in this. After this process completes, the end products will get eliminated rapidly in your urine.